PE-22-28
PE-22-28 is a synthetic analog of Spadin, a naturally occurring peptide that inhibits the TREK-1 potassium channel. TREK-1 inhibition has been shown to produce rapid antidepressant effects and promote neurogenesis in the hippocampus. Unlike traditional SSRIs that take weeks to work, PE-22-28 may produce mood improvements within days. It also enhances BDNF signaling and has been shown to improve cognitive function in animal models.
Frequency
Daily
Cycle Length
4-8 weeks on, 2-4 weeks off
Route
Subcutaneous
Research Level
Experimental
Goals
Dosing Protocol
300 mcg to 1 mg daily (3-10 units). With standard reconstitution (10 mg in 1 mL), 0.1 mg per unit — 3 units = 300 mcg, 10 units = 1 mg on a U-100 insulin syringe. Innovative peptide for neuroprotection, cognitive support and mood enhancement.
Reconstitution
Add 1 mL bacteriostatic water to a 10 mg vial.
Timing
Morning or early afternoon.
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Potential Side Effects
- Limited human data
- Mild anxiety initially in some users
- Injection site irritation
Important Warnings
- No human clinical trials
- Do not combine with SSRIs or other antidepressants without medical guidance
Works Well With
Research References
- Mazella J, et al. PLoS One. 2010;5(7):e11851. doi:10.1371/journal.pone.0011851
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Medical Disclaimer: This information is for educational purposes only and is not intended as medical advice. PE-22-28 may be regulated differently in various jurisdictions. Always consult with a qualified healthcare provider before beginning any peptide protocol. PepStack Pro does not sell peptides or provide medical advice. Content reviewed by Dr. Seth Miller, MD.