PNC-28
PNC-28 is a synthetic peptide derived from the p53 tumor suppressor protein (residues 17-26). It specifically targets the HDM2 binding site on cancer cells, triggering selective necrosis (cell death) in tumor cells while leaving healthy cells unharmed. In vitro studies have shown PNC-28 to be effective against pancreatic cancer, breast cancer, melanoma, and other cancer cell lines. It represents a targeted approach to cancer therapy that exploits the universal overexpression of HDM2 in cancer cells.
Frequency
Once daily
Cycle Length
Use until vial is gone. Research-stage compound.
Route
Subcutaneous
Research Level
Experimental
Goals
Dosing Protocol
1-2 mg daily, subcutaneously. Use until vial is gone. With standard reconstitution (20 mg in 2 mL), 1 mg = 10 units and 2 mg = 20 units on a U-100 insulin syringe.
Reconstitution
Add 2 mL bacteriostatic water to a 20 mg vial.
Timing
Per provider protocol.
Get complete, interactive protocols in the PepStack Pro app.
Potential Side Effects
- Limited human clinical data
- Injection site reaction
- Use under medical supervision only
Important Warnings
- Experimental — no human clinical trials completed
- Must be used under oncological supervision only
- Not a substitute for conventional cancer treatment
Research References
- Kanovsky M, et al. Proc Natl Acad Sci USA. 2001;98(22):12438-12443. doi:10.1073/pnas.211407398
Not sure which peptides are right for you?
Take our free protocol quiz to get personalized recommendations based on your goals.
Get Full Protocols in the App
Unlock interactive dosing calculators, injection tracking, stacking guides, and lab monitoring for PNC-28 and 60+ other peptides.
Connect with a Physician
Work with a board-certified physician who specializes in peptide therapy through MyFlowMD. Get a personalized PNC-28 protocol.
Related Peptides
Explore commonly stacked compounds and nearby options with similar goals or mechanisms.
Thymosin Alpha 1
Immune system modulator for enhanced pathogen defense.
Epithalon
Telomerase activator for longevity and improved sleep cycles.
Thymalin
Thymic bioregulator peptide for immune system restoration and longevity.
Thymulin
Thymic peptide hormone for immune regulation and anti-inflammatory action.
Medical Disclaimer: This information is for educational purposes only and is not intended as medical advice. PNC-28 may be regulated differently in various jurisdictions. Always consult with a qualified healthcare provider before beginning any peptide protocol. PepStack Pro does not sell peptides or provide medical advice. Content reviewed by Dr. Seth Miller, MD.