TB-500
TB-500 is a synthetic version of the naturally occurring peptide Thymosin Beta-4. It plays a key role in tissue repair by promoting cell migration, blood vessel formation, and reducing inflammation. TB-500 is particularly effective for muscle, tendon, and ligament injuries, and is known for its systemic healing properties — meaning it can reach injured areas throughout the body regardless of injection site.
Frequency
Twice per week
Cycle Length
6-8 weeks loading, then as needed for maintenance
Route
Subcutaneous
Research Level
Established
Goals
Dosing Protocol
2.5-5 mg per injection (50-100 units), twice per week. Works in synergy with BPC-157. With standard reconstitution (5 mg in 1 mL), 0.05 mg per unit — 50 units = 2.5 mg, 100 units = 5 mg (full syringe) on a U-100 insulin syringe.
Reconstitution
Add 1 mL bacteriostatic water to a 5 mg vial.
Timing
Can be taken any time of day. Injection site does not need to be near the injury.
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Potential Side Effects
- Head rush shortly after injection
- Temporary lethargy
- Mild irritation at injection site
Important Warnings
- Not FDA-approved
- WADA-prohibited substance
- Theoretical concern about promoting existing tumor growth — avoid with active cancer
Frequently Asked Questions
What is TB-500 typically used for?
TB-500 is typically used for systemic tissue repair and recovery. It is popular for muscle, tendon, and ligament injuries because it is intended to support healing throughout the body rather than only at the injection site.
Does TB-500 need to be injected near the injury?
No. TB-500 is usually described as systemic, so people do not typically target the exact injury site the way they sometimes do with other recovery compounds.
How is TB-500 commonly dosed?
A common starting framework is 2.5 to 5 mg per injection twice per week during a loading phase, with the exact protocol adjusted based on recovery goals, source concentration, and clinician oversight.
Do people stack TB-500 with BPC-157?
Yes. TB-500 is one of the most common BPC-157 stack partners because the two are often used together for soft-tissue healing and recovery-focused protocols.
Research References
- Goldstein AL, et al. Expert Opin Biol Ther. 2012;12(S1):S37-S51. doi:10.1517/14712598.2012.697150
- Philp D, et al. FASEB J. 2004;18(2):405-407. doi:10.1096/fj.03-0510fje
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Related Peptides
Explore commonly stacked compounds and nearby options with similar goals or mechanisms.
BPC-157
Powerful healing peptide for gut, joints, and tissue repair.
Wolverine Blend (BPC-157 + TB-500)
The classic healing duo for injury recovery, joint repair, and gut health.
KLOW Blend (BPC-157 + TB-500 + GHK-Cu + KPV)
Comprehensive healing blend with added anti-inflammatory and gut support.
MGF (Mechano Growth Factor)
IGF-1 splice variant that activates muscle satellite cells for repair.
Medical Disclaimer: This information is for educational purposes only and is not intended as medical advice. TB-500 may be regulated differently in various jurisdictions. Always consult with a qualified healthcare provider before beginning any peptide protocol. PepStack Pro does not sell peptides or provide medical advice. Content reviewed by Dr. Seth Miller, MD.