Tesamorelin
Tesamorelin is a growth hormone-releasing hormone (GHRH) analog that has been extensively studied for reducing visceral adipose tissue. It stimulates the pituitary to produce and release growth hormone in a more physiological pulsatile pattern. Tesamorelin is particularly effective at targeting stubborn abdominal fat while preserving lean muscle mass, and has shown cognitive benefits in studies as well.
Frequency
Once daily — 5 days on, 2 days off per week
Cycle Length
12-26 weeks. Can be used long-term under supervision.
Route
Subcutaneous
Research Level
Established
Goals
Dosing Protocol
1-2 mg daily (12-25 units). With standard reconstitution (8 mg in 1 mL), 0.08 mg per unit — 12 units = ~1 mg, 25 units = 2 mg. For 10 mg vial in 1 mL, 0.1 mg per unit — 10 units = 1 mg, 20 units = 2 mg. 5 days on, 2 days off.
Reconstitution
Add 1 mL bacteriostatic water to an 8 mg or 10 mg vial.
Timing
Taken before bedtime.
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Potential Side Effects
- Injection site reactions
- Joint pain
- Peripheral edema
- Paresthesia
Important Warnings
- FDA-approved for HIV-associated lipodystrophy only
- Do not use with active cancer or pituitary tumors
Works Well With
Research References
- Falutz J, et al. N Engl J Med. 2007;357(23):2359-2370. doi:10.1056/NEJMoa072191
- Stanley TL, et al. Lancet HIV. 2015;2(6):e259-e265. doi:10.1016/S2352-3018(15)00072-2
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Medical Disclaimer: This information is for educational purposes only and is not intended as medical advice. Tesamorelin may be regulated differently in various jurisdictions. Always consult with a qualified healthcare provider before beginning any peptide protocol. PepStack Pro does not sell peptides or provide medical advice. Content reviewed by Dr. Seth Miller, MD.