VIP (Vasoactive Intestinal Peptide)
Vasoactive Intestinal Peptide is a 28-amino acid neuropeptide with potent anti-inflammatory, immune-modulating, and neuroprotective properties. It is best known in the context of Chronic Inflammatory Response Syndrome (CIRS) / mold illness, where it is the final step in the Shoemaker Protocol. VIP regulates innate immune responses, reduces pulmonary artery pressure, improves regulatory T-cell function, and normalizes inflammatory cytokines. It also supports gut barrier integrity and has vasodilatory effects.
Frequency
4x daily (intranasal) or per provider protocol
Cycle Length
30 days or longer. Used as final step in CIRS/Shoemaker Protocol.
Route
Nasal
Research Level
Emerging
Goals
Dosing Protocol
Intranasal: 50 mcg per spray, 4 sprays per day (200 mcg total). Some protocols use subcutaneous injection. Follow provider protocol.
Reconstitution
Intranasal: typically pre-mixed. Injectable: per provider instructions.
Timing
Spread throughout the day (intranasal).
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Potential Side Effects
- Nasal irritation
- Mild diarrhea
- Cough
- Low blood pressure (vasodilation)
- Should not be started if CIRS markers are not first normalized
Important Warnings
- For CIRS protocol: do not start until MARCoNS, C4a, and TGF-beta are normalized
- Can cause significant blood pressure drop — use caution if hypotensive
Works Well With
Research References
- Shoemaker RC, House D, Ryan JC. Intern Med Rev. 2013;9:33-47.
- Delgado M, et al. Nat Med. 2001;7(5):563-568. doi:10.1038/87887
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Medical Disclaimer: This information is for educational purposes only and is not intended as medical advice. VIP (Vasoactive Intestinal Peptide) may be regulated differently in various jurisdictions. Always consult with a qualified healthcare provider before beginning any peptide protocol. PepStack Pro does not sell peptides or provide medical advice. Content reviewed by Dr. Seth Miller, MD.