KPV
KPV is a tripeptide fragment (Lys-Pro-Val) derived from alpha-MSH (melanocyte-stimulating hormone). Despite its small size, KPV is a potent anti-inflammatory agent that works by entering immune cells and blocking NF-kB activation, a master regulator of inflammatory pathways. It has shown remarkable results for inflammatory bowel conditions, skin inflammation, and general systemic inflammation reduction. Available in oral, topical, and injectable forms.
Frequency
Based on injury — after surgery, preventative, or during illness
Cycle Length
4-8 weeks for inflammatory conditions. Can be used longer-term for gut support.
Route
Oral
Research Level
Established
Goals
Dosing Protocol
Injectable: 200-500 mcg subcutaneously per dose (4-10 units). Based on immunity needs — after surgery, preventative, or during illness. With standard reconstitution (5 mg in 1 mL), 0.05 mg per unit — 4 units = 200 mcg, 10 units = 500 mcg on a U-100 insulin syringe. Also available in 10 mg vials (10 mg in 1 mL, 0.1 mg per unit).
Reconstitution
Add 1 mL bacteriostatic water to a 5 mg vial, or 1 mL to a 10 mg vial.
Timing
Oral: on an empty stomach, 30 minutes before meals.
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Potential Side Effects
- Very minimal side effects reported
- Mild GI changes when starting oral route
Important Warnings
- Not FDA-approved
Works Well With
Research References
- Brzoska T, et al. Endocr Rev. 2008;29(5):581-602. doi:10.1210/er.2007-0027
- Kannengiesser K, et al. Ann N Y Acad Sci. 2007;1110(1):408-415. doi:10.1196/annals.1423.043
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Medical Disclaimer: This information is for educational purposes only and is not intended as medical advice. KPV may be regulated differently in various jurisdictions. Always consult with a qualified healthcare provider before beginning any peptide protocol. PepStack Pro does not sell peptides or provide medical advice. Content reviewed by Dr. Seth Miller, MD.