FOXO4-DRI
FOXO4-DRI is a synthetic peptide that disrupts the interaction between FOXO4 and p53 proteins in senescent (aged, damaged) cells. Senescent cells accumulate with age and secrete inflammatory factors that damage surrounding tissue. By blocking the FOXO4-p53 interaction, this peptide causes senescent cells to undergo apoptosis (programmed cell death) while leaving healthy cells unaffected. This selective clearance has shown rejuvenating effects in preclinical studies.
Frequency
Every other day
Cycle Length
1 bottle cycle, 1-3 times per year.
Route
Subcutaneous
Research Level
Experimental
Goals
Dosing Protocol
3 mg per injection, every other day. 1 bottle cycle (15 mg vial in 1.5 mL). Do cycle 1-3 times per year. Frequency and dosage can vary by situation.
Reconstitution
Add 1.5 mL bacteriostatic water to a 15 mg vial.
Timing
Morning, on an empty stomach.
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Potential Side Effects
- Very limited human data
- Theoretical risk of disrupting tumor suppression
- Diarrhea reported anecdotally
Important Warnings
- No human clinical trials completed
- Theoretical cancer risk — targets p53 tumor suppressor pathway
- Not for use by individuals with active malignancies
Works Well With
Research References
- Baar MP, et al. Cell. 2017;169(1):132-147.e16. doi:10.1016/j.cell.2017.02.031
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Medical Disclaimer: This information is for educational purposes only and is not intended as medical advice. FOXO4-DRI may be regulated differently in various jurisdictions. Always consult with a qualified healthcare provider before beginning any peptide protocol. PepStack Pro does not sell peptides or provide medical advice. Content reviewed by Dr. Seth Miller, MD.