Kisspeptin-10
Kisspeptin is a neuropeptide that acts as a master regulator of the reproductive axis by stimulating GnRH (gonadotropin-releasing hormone) release. It plays a crucial role in puberty onset, fertility, and sexual behavior. Kisspeptin-10 is the active fragment that has been studied for treating hypogonadism, female infertility, and low libido. Unlike direct testosterone or estrogen supplementation, it works upstream to naturally optimize reproductive hormone production.
Frequency
When needed
Cycle Length
As-needed dosing. Can also be used in 4-8 week cycles.
Route
Subcutaneous
Research Level
Emerging
Goals
Dosing Protocol
100-200 mcg per injection (4-8 units), when needed. For 5 mg vial reconstituted with 2 mL, 0.025 mg per unit — 4 units = 100 mcg, 8 units = 200 mcg. For 10 mg vial reconstituted with 4 mL, 0.025 mg per unit — same dosing. Effective peptide for hormone balance, reproductive health, and wellness.
Reconstitution
Add 2 mL bacteriostatic water to a 5 mg vial, or 4 mL to a 10 mg vial.
Timing
Morning for hormonal optimization. Evening for acute libido effects.
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Potential Side Effects
- Facial flushing
- Mild headache
- Generally well tolerated
Important Warnings
- Not FDA-approved
- May disrupt hormonal balance if misused
- Not for use during pregnancy
Works Well With
Research References
- Dhillo WS, et al. J Clin Endocrinol Metab. 2005;90(12):6609-6615. doi:10.1210/jc.2005-1468
- Jayasena CN, et al. J Clin Invest. 2014;124(8):3667-3677. doi:10.1172/JCI75730
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Medical Disclaimer: This information is for educational purposes only and is not intended as medical advice. Kisspeptin-10 may be regulated differently in various jurisdictions. Always consult with a qualified healthcare provider before beginning any peptide protocol. PepStack Pro does not sell peptides or provide medical advice. Content reviewed by Dr. Seth Miller, MD.