PT-141 (Bremelanotide)
PT-141 (Bremelanotide) is a melanocortin receptor agonist derived from Melanotan II, but specifically designed for sexual dysfunction. Unlike PDE5 inhibitors (Viagra, Cialis) that work on blood flow, PT-141 works centrally in the brain by activating MC3 and MC4 receptors involved in sexual arousal. It is effective for both men and women, and is FDA-approved as Vyleesi for hypoactive sexual desire disorder in premenopausal women.
Frequency
As needed, no more than once per 24 hours, max 8x per month.
Cycle Length
As needed basis. Not for daily use.
Route
Subcutaneous
Research Level
Established
Goals
Dosing Protocol
500 mcg to 1 mg per use (10-20 units), as needed 2 hours before sexual activity. For 5 mg vial reconstituted with 1 mL, 0.05 mg per unit — 10 units = 500 mcg. For 10 mg vial reconstituted with 2 mL, 0.05 mg per unit — 10 units = 500 mcg, 20 units = 1 mg. Do not exceed 20 units. Consult with doctor.
Reconstitution
Add 1 mL bacteriostatic water to a 5 mg vial, or 2 mL to a 10 mg vial.
Timing
2 hours before sexual activity.
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Potential Side Effects
- Nausea (most common)
- Facial flushing
- Headache
- Slight blood pressure increase
Important Warnings
- FDA-approved only for premenopausal women with HSDD (as Vyleesi)
- Do not use more than once in 24 hours or more than 8 times per month
- May cause transient blood pressure increase
- Not for use during pregnancy
Works Well With
Research References
- Kingsberg SA, et al. Obstet Gynecol. 2019;134(5):899-908. doi:10.1097/AOG.0000000000003500
- Clayton AH, et al. J Sex Med. 2016;13(12):1897-1906. doi:10.1016/j.jsxm.2016.10.001
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Medical Disclaimer: This information is for educational purposes only and is not intended as medical advice. PT-141 (Bremelanotide) may be regulated differently in various jurisdictions. Always consult with a qualified healthcare provider before beginning any peptide protocol. PepStack Pro does not sell peptides or provide medical advice. Content reviewed by Dr. Seth Miller, MD.